EcoToxChip Project
The EcoToxChip Project aims to develop, test, validate, and commercialize quantitative PCR arrays (EcoToxChips) and a data evaluation tool (EcoToxXplorer.ca) for the characterization, prioritization, and management of environmental chemicals and complex mixtures of regulatory concern.
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High Throughput Hazard Profiling
We focus on the development of scalable microplate-based technologies that enable a large number of samples to be evaluated for hazard potential, with key examples being:
a. OECD249 - RTgill-W1 cell line, coupled with transcriptomics measures [funded by NSERC] b. Neurochemical receptor/enzyme screens [funded by US EPA STAR] c. Various cell lines linked with QIAGEN's UPX panel for transcriptomic points of departure [funded by Genome Quebec] |
Online Bioinformatics Tools
We collaborate with Prof. Xia's team at McGill - as users and biologists - to help design and test cloud-based tools to analyze genomics data. Projects are largely funded by Genome Canada and Genome Quebec, with some key efforts including:
a. EcoToxXplorer.ca - helps interpret results from EcoToxChips, including EcoToxModules and AOP flags. b. EcoOmicsAnalyst.ca - enables RNAseq analysis from ANY species. c. FastBMD.ca - facilitates the derivation of transcriptomics points of departure. |