Mark Bradley
Doctoral Student, McGill University
Mercury Bioavailability from Seafood
[email protected]
Doctoral Student, McGill University
Mercury Bioavailability from Seafood
[email protected]
A) Educational Background
PhD McGill University, Sainte-Anne-de-Bellevue, QC, Canada (2013-present)
Faculty of Agricultural and Environmental Sciences
School of Human Nutrition
MPH University of Michigan School of Public Health, Ann Arbor, MI, USA (2011-2013)
Department of Environmental Health Sciences
Concentration: Toxicology
BS University of Michigan, Ann Arbor, MI, USA (2008-2011)
Major: Program in the Environment (Specialization: Environmental Health)
Minor: Ecology and Evolutionary Biology
Faculty of Agricultural and Environmental Sciences
School of Human Nutrition
MPH University of Michigan School of Public Health, Ann Arbor, MI, USA (2011-2013)
Department of Environmental Health Sciences
Concentration: Toxicology
BS University of Michigan, Ann Arbor, MI, USA (2008-2011)
Major: Program in the Environment (Specialization: Environmental Health)
Minor: Ecology and Evolutionary Biology
B) Research Interests and Current Projects
My current research interests include the role of both intrinsic and extrinsic factors in inter-individual variation in exposure and response to environmental contaminants. At McGill, my research investigates mercury toxicokinetics as modified by the environment of the human gut, with attention to the roles dietary and microbial factors may play in driving inter-individual variability in mercury toxicokinetics.
Beyond my current research, I am interested in: 1) nutrient-toxicant interactions and toxicity of chemical mixtures; 2) intestinal microbial community function; 3) the interplay between the gut microbiome and the immune system; 4) development of in vitro and in silico toxicology methods, particularly for metals; 5) wildlife toxicology, particularly avian toxicology; and 6) neurobehavioral toxicology.
Beyond my current research, I am interested in: 1) nutrient-toxicant interactions and toxicity of chemical mixtures; 2) intestinal microbial community function; 3) the interplay between the gut microbiome and the immune system; 4) development of in vitro and in silico toxicology methods, particularly for metals; 5) wildlife toxicology, particularly avian toxicology; and 6) neurobehavioral toxicology.
C) Honours and Awards
2013-2017 Catherine Freeman Graduate Research Fellowship (McGill University)
2013-2017 Graduate Excellence Fellowship (McGill University)
2013-2016 Differential Fee Waiver (McGill University)
2013 Society of Environmental Toxicology and Chemistry Endowment Fund Student Travel Award (SETAC)
2011-2013 Dean’s Research Opportunity Award (University of Michigan School of Public Health)
2011-2013 School of Public Health Dean’s Award (University of Michigan School of Public Health)
2012 Marian P. and David M. Gates Graduate Student Research Fund Grant (University of Michigan Biological Station; declined)
2012 Phi Beta Kappa Honor Society (University of Michigan)
2011 Graduation with High Distinction (University of Michgian)
2011 Phi Kappa Phi Honor Society (University of Michigan)
2008-2011 Robert C. Byrd Honors Scholarship (State of Michigan)
2010 Biological Station Scholarship (University of Michigan Biological Station)
2010 Environmental Experience Scholarship (University of Michigan)
2010 James B. Angell Scholar (University of Michigan)
2008-2010 University Honors (University of Michigan)
2009-2010 Michigan Competitive Scholarship (State of Michigan)
2009-2010 Michigan Grant (University of Michigan)
2008-2009 Michigan Promise Scholarship (State of Michigan)
2009 Undergraduate Research Opportunities Program (UROP), Symposium Award
2008 Congressional Medal of Merit (U.S.)
2013-2017 Graduate Excellence Fellowship (McGill University)
2013-2016 Differential Fee Waiver (McGill University)
2013 Society of Environmental Toxicology and Chemistry Endowment Fund Student Travel Award (SETAC)
2011-2013 Dean’s Research Opportunity Award (University of Michigan School of Public Health)
2011-2013 School of Public Health Dean’s Award (University of Michigan School of Public Health)
2012 Marian P. and David M. Gates Graduate Student Research Fund Grant (University of Michigan Biological Station; declined)
2012 Phi Beta Kappa Honor Society (University of Michigan)
2011 Graduation with High Distinction (University of Michgian)
2011 Phi Kappa Phi Honor Society (University of Michigan)
2008-2011 Robert C. Byrd Honors Scholarship (State of Michigan)
2010 Biological Station Scholarship (University of Michigan Biological Station)
2010 Environmental Experience Scholarship (University of Michigan)
2010 James B. Angell Scholar (University of Michigan)
2008-2010 University Honors (University of Michigan)
2009-2010 Michigan Competitive Scholarship (State of Michigan)
2009-2010 Michigan Grant (University of Michigan)
2008-2009 Michigan Promise Scholarship (State of Michigan)
2009 Undergraduate Research Opportunities Program (UROP), Symposium Award
2008 Congressional Medal of Merit (U.S.)
D) Previous Research and Professional Experience
2012-2013 Masters Research Student, University of Michigan School of Public Health Computational Toxicology Lab
2012-2013 Masters Research Student, Graham Environmental Sustainability Institute, Hydraulic Fracturing Integrated Assessment Public Health
Technical Report Team
2011-2013 Masters Research Student, University of Michigan School of Public Health Environmental Toxicology Lab
2011-2012 Teaching Assistant, Natural History and Evolution, University of Michigan Biological Station
2010-2011 Session co-organizer and co-lead: “Transportation and Public Health,” Transforming Transportation: Economies and Communities
Conference
2010 Undergraduate Student Field Researcher, University of Michigan Biological Station
2008-2010 Undergraduate Research Assistant, University of Michigan Biologic and Materials Sciences/ Biomedical Engineering Lab
2012-2013 Masters Research Student, Graham Environmental Sustainability Institute, Hydraulic Fracturing Integrated Assessment Public Health
Technical Report Team
2011-2013 Masters Research Student, University of Michigan School of Public Health Environmental Toxicology Lab
2011-2012 Teaching Assistant, Natural History and Evolution, University of Michigan Biological Station
2010-2011 Session co-organizer and co-lead: “Transportation and Public Health,” Transforming Transportation: Economies and Communities
Conference
2010 Undergraduate Student Field Researcher, University of Michigan Biological Station
2008-2010 Undergraduate Research Assistant, University of Michigan Biologic and Materials Sciences/ Biomedical Engineering Lab
E) Publications and Presentations
Bradley, M., Siedlikowski, M., Basu, N. 2017. Bioavailability of methylmercury from commonly consumed seafood: an in vitro investigation of gastrointestinal and colonic digestion. 13th International Conference on Mercury as a Global Pollutant. Providence, Rhode Island, United States. July 16-21, 2017. [TALK]
Bradley, M., Park, S.K., Basu. N. 2017. Is pharmaceutical use associated with mercury exposure? An epidemiological investigation using U.S. NHANES. 13th International Conference on Mercury as a Global Pollutant. Providence, Rhode Island, United States. July 16-21, 2017. [POSTER]
Golzadeh, N., Bradley, M., Baker, J., Basu, N. 2017. In vitro bioaccessibility of mercury from traditional foods of Bigstone Cree Firs Nation (Albertan, Canada). 13th International Conference on Mercury as a Global Pollutant. Providence, Rhode Island, United States. July 16-21, 2017. [POSTER]
Bradley, M., Siedlikowski, M., Basu, N. 2017. Bioavailability of methylmercury from commonly consumed seafood: an in vitro investigation of gastrointestinal and colonic digestion. 56th Annual Society of Toxicology Meeting. Baltimore, Maryland, United States. March 12-16 2017. [POSTER]
Bradley, M., Barst, B. Basu, N. 2017. A review of mercury bioavailability in humans and fish. International Journal of Environmental Research and Public Health.14,169. LINK
Bradley, M., Siedlikowski, M., Basu, N. 2016. Bioavailability of methylmercury from commonly consumed seafood: an in vitro investigation of gastrointestinal and colonic digestion. 55th Annual Society of Toxicology Meeting. New Orleans, Louisiana, United States. March 13-17 2016. [POSTER]
Siedlikowski, M., Bradley, M., Kubow, S., Goodrich, J.M., Franzblau, A., Basu, N. 2016. Bioaccessibility and bioavailability of methylmercury from seafood commonly consumed in North America: In vitro and epidemiological studies. Environmental Research. 149: 266-273 LINK.
Bradley, M., Rutkiewicz, J., Mittal, K., Fernie, K., Basu, N. 2015. In ovo exposure to organophosphorous flame retardants: survival, development, neurochemical, and behavioral changes in white leghorn chickens. Neurotoxicology and Teratology. 52: 228-235. LINK
Siedllikowski, M., Bradley, M., Basu. N. 2015. Investigating bioaccessibility of methylmercury from seafood commonly consumed in North America. 79th American Society for Nutrition Scientific Sessions at Experimental Biology. Boston, Massachusetts, United States. March 28-April 1 2015. [Poster]
Bradley, M., Siedllikowski, M., Park, S.K., Basu. N. 2015. Does Does pharmaceutical exposure mediate risks associated with exposure to heavy metals? An epidemiological investigation of NHANES. 54th Annual Society of Toxicology Meeting. San Diego, California, United States. March 22-26 2015. [Poster]
Bradley, M., Siedllikowski, M., Basu. N. 2015. In vitro studies to characterize the bioaccessibility and bioavailability of methylmercury from seafood. 54th Annual Society of Toxicology Meeting. San Diego, California, United States. March 22-26 2015. [Poster]
Bradley, M., Siedlikowski, M., Park, S.K., Basu, N. 2014. Does pharmaceutical exposure mediate risks associated with exposure to heavy metals? An epidemiological investigation. 41st Annual Aquatic Toxicity Workshop (ATW). Ottawa, Canada. Sept 28-Oct 1, 2014. [Platform]
Siedlikowski M., Bradley, M., Basu, N. Investigating bioaccessibility and bioavailability of methylmercury from commonly consumed fish and seafood in North America. 41st Annual Aquatic Toxicity Workshop, ATW. Ottawa, Ontario, Canada. Sep 29 - Oct 01 2014. [Platform]
Bradley, M., Siedlikowski, M., Park, S.K., Basu, N. EcoHealth implications of mixing prescription drugs with toxic heavy metals – an epidemiological analysis of NHANES. 5th Biennial Conference of the International Association for Ecology and Health, EcoHealth. Montreal, Quebec, Canada. Aug 11-15 2014. [Platform]
Siedlikowski M., Bradley, M., Basu, N. Investigating bioaccessibility and bioavailability of methylmercury from commonly consumed fish and seafood in North America. 5th Biennial Conference of the International Association for Ecology and Health, EcoHealth. Montreal, Quebec, Canada. Aug 11-15 2014. [Platform]
Bradley, M., Rutkiewicz, J., Mittal, K., Fernie, K., Crump, D., Basu, N. In ovo exposure to organophosphorous flame retardants: survival, development, neurochemical and behavioral changes in white leghorn chicken hatchlings, 34th Annual Meeting, Society of Environmental Toxicology and Chemistry (SETAC). Nashville, Tennessee, United States. Nov 17-22 2013. [Platform]
Bradley M., Faulkner D., Wijeyesakere S., Johnson, D., Richardson, R. In silico modeling of manganese- and iron-binding properties of a designed peptide inspired by the radioresistant bacterium Deinococcus radiodurans. 34th Annual Meeting, Society of Environmental Toxicology and Chemistry (SETAC). Nashville, Tennessee, United States. Nov 17-22 2013. [Poster]
Basu, N., Bradley, M., McFeely, C., Perkins, M. 2013. Public Health and Hydraulic Fracturing in Michigan. In "Hydraulic Fracturing in the State of Michigan". Peer-reviewed. Graham Environmental Sustainability Institute, University of Michigan. 37 pp.[http://www.graham.umich.edu/knowledge/ia/hydraulic-fracturing/technical-reports]
Rutkiewicz, J., Bradley, M., Mittal, K., Basu, N. 2013. Methylmercury egg injections: Part 2-Pathology, neurochemistry, and behavior in the avian embryo and hatchling. Ecotoxicology and Environmental Safety 93, 77-86.
Bradley, M., Huang, L., Rutkiewicz, J., Mittal, K., Chernyak, S., Batterman, S., Basu, N. In ovo exposure to 1-nitropyrene: biochemical, developmental, behavioral, and lethal changes in white leghorn chicken hatchlings, 33rd Annual Meeting, Society of Environmental Toxicology and Chemistry (SETAC). Long Beach, California, United States. Nov 2012. [Poster]
Rutkiewicz J, Bradley M., Mittal K, Basu N. In ovo exposure to methylmercury chloride is not associated with neurological changes in white leghorn chicken hatchlings. 33rd Annual Meeting, Society of Environmental Toxicology and Chemistry (SETAC), Long Beach, California, United States, Nov 2012. [Poster]
Rutkiewicz J, Bradley M., Head J, Mittal K, Nam D, Basu N. Distribution of mercury in the chicken embryo and hatchling following methylmercury chloride egg injection. 33rd Annual Meeting, Society of Environmental Toxicology and Chemistry (SETAC), Boston, Massachusetts, United States, Nov 2011. [Poster]
Feng, K., Sun, H., Bradley, M., Dupler, E., Giannobile, W.V., Ma, P.X. 2010. Novel anti-bacterial nanofibrous PLLA scaffolds. Journal of Controlled Release 146, 363-369. LINK
Bradley, M., David, A., Heeren, T. Assessment of differences in microhabitat preferences between Drosera rotundifolia and Drosera intermedia in a northern Michigan bog. University of Michigan Biological Station Symposium, Aug 2010. [Platform]
Ma, P.X., Feng, K., and Bradley, M. Development and characterization of novel anti-bacterial PLLA nanofibrous scaffolds,Undergraduate Research Opportunities Program Symposium, Apr 2010. [Poster]
Ma, P.X., Feng, K., Bradley, M., and Dupler, E. Macroporous and nanofibrous polymer scaffolds and polymer/bone-like apatite composite scaffolds generated by sugar spheres. Undergraduate Research Opportunities Program Symposium, Apr 2009. [Poster]
Bradley, M., Park, S.K., Basu. N. 2017. Is pharmaceutical use associated with mercury exposure? An epidemiological investigation using U.S. NHANES. 13th International Conference on Mercury as a Global Pollutant. Providence, Rhode Island, United States. July 16-21, 2017. [POSTER]
Golzadeh, N., Bradley, M., Baker, J., Basu, N. 2017. In vitro bioaccessibility of mercury from traditional foods of Bigstone Cree Firs Nation (Albertan, Canada). 13th International Conference on Mercury as a Global Pollutant. Providence, Rhode Island, United States. July 16-21, 2017. [POSTER]
Bradley, M., Siedlikowski, M., Basu, N. 2017. Bioavailability of methylmercury from commonly consumed seafood: an in vitro investigation of gastrointestinal and colonic digestion. 56th Annual Society of Toxicology Meeting. Baltimore, Maryland, United States. March 12-16 2017. [POSTER]
Bradley, M., Barst, B. Basu, N. 2017. A review of mercury bioavailability in humans and fish. International Journal of Environmental Research and Public Health.14,169. LINK
Bradley, M., Siedlikowski, M., Basu, N. 2016. Bioavailability of methylmercury from commonly consumed seafood: an in vitro investigation of gastrointestinal and colonic digestion. 55th Annual Society of Toxicology Meeting. New Orleans, Louisiana, United States. March 13-17 2016. [POSTER]
Siedlikowski, M., Bradley, M., Kubow, S., Goodrich, J.M., Franzblau, A., Basu, N. 2016. Bioaccessibility and bioavailability of methylmercury from seafood commonly consumed in North America: In vitro and epidemiological studies. Environmental Research. 149: 266-273 LINK.
Bradley, M., Rutkiewicz, J., Mittal, K., Fernie, K., Basu, N. 2015. In ovo exposure to organophosphorous flame retardants: survival, development, neurochemical, and behavioral changes in white leghorn chickens. Neurotoxicology and Teratology. 52: 228-235. LINK
Siedllikowski, M., Bradley, M., Basu. N. 2015. Investigating bioaccessibility of methylmercury from seafood commonly consumed in North America. 79th American Society for Nutrition Scientific Sessions at Experimental Biology. Boston, Massachusetts, United States. March 28-April 1 2015. [Poster]
Bradley, M., Siedllikowski, M., Park, S.K., Basu. N. 2015. Does Does pharmaceutical exposure mediate risks associated with exposure to heavy metals? An epidemiological investigation of NHANES. 54th Annual Society of Toxicology Meeting. San Diego, California, United States. March 22-26 2015. [Poster]
Bradley, M., Siedllikowski, M., Basu. N. 2015. In vitro studies to characterize the bioaccessibility and bioavailability of methylmercury from seafood. 54th Annual Society of Toxicology Meeting. San Diego, California, United States. March 22-26 2015. [Poster]
Bradley, M., Siedlikowski, M., Park, S.K., Basu, N. 2014. Does pharmaceutical exposure mediate risks associated with exposure to heavy metals? An epidemiological investigation. 41st Annual Aquatic Toxicity Workshop (ATW). Ottawa, Canada. Sept 28-Oct 1, 2014. [Platform]
Siedlikowski M., Bradley, M., Basu, N. Investigating bioaccessibility and bioavailability of methylmercury from commonly consumed fish and seafood in North America. 41st Annual Aquatic Toxicity Workshop, ATW. Ottawa, Ontario, Canada. Sep 29 - Oct 01 2014. [Platform]
Bradley, M., Siedlikowski, M., Park, S.K., Basu, N. EcoHealth implications of mixing prescription drugs with toxic heavy metals – an epidemiological analysis of NHANES. 5th Biennial Conference of the International Association for Ecology and Health, EcoHealth. Montreal, Quebec, Canada. Aug 11-15 2014. [Platform]
Siedlikowski M., Bradley, M., Basu, N. Investigating bioaccessibility and bioavailability of methylmercury from commonly consumed fish and seafood in North America. 5th Biennial Conference of the International Association for Ecology and Health, EcoHealth. Montreal, Quebec, Canada. Aug 11-15 2014. [Platform]
Bradley, M., Rutkiewicz, J., Mittal, K., Fernie, K., Crump, D., Basu, N. In ovo exposure to organophosphorous flame retardants: survival, development, neurochemical and behavioral changes in white leghorn chicken hatchlings, 34th Annual Meeting, Society of Environmental Toxicology and Chemistry (SETAC). Nashville, Tennessee, United States. Nov 17-22 2013. [Platform]
Bradley M., Faulkner D., Wijeyesakere S., Johnson, D., Richardson, R. In silico modeling of manganese- and iron-binding properties of a designed peptide inspired by the radioresistant bacterium Deinococcus radiodurans. 34th Annual Meeting, Society of Environmental Toxicology and Chemistry (SETAC). Nashville, Tennessee, United States. Nov 17-22 2013. [Poster]
Basu, N., Bradley, M., McFeely, C., Perkins, M. 2013. Public Health and Hydraulic Fracturing in Michigan. In "Hydraulic Fracturing in the State of Michigan". Peer-reviewed. Graham Environmental Sustainability Institute, University of Michigan. 37 pp.[http://www.graham.umich.edu/knowledge/ia/hydraulic-fracturing/technical-reports]
Rutkiewicz, J., Bradley, M., Mittal, K., Basu, N. 2013. Methylmercury egg injections: Part 2-Pathology, neurochemistry, and behavior in the avian embryo and hatchling. Ecotoxicology and Environmental Safety 93, 77-86.
Bradley, M., Huang, L., Rutkiewicz, J., Mittal, K., Chernyak, S., Batterman, S., Basu, N. In ovo exposure to 1-nitropyrene: biochemical, developmental, behavioral, and lethal changes in white leghorn chicken hatchlings, 33rd Annual Meeting, Society of Environmental Toxicology and Chemistry (SETAC). Long Beach, California, United States. Nov 2012. [Poster]
Rutkiewicz J, Bradley M., Mittal K, Basu N. In ovo exposure to methylmercury chloride is not associated with neurological changes in white leghorn chicken hatchlings. 33rd Annual Meeting, Society of Environmental Toxicology and Chemistry (SETAC), Long Beach, California, United States, Nov 2012. [Poster]
Rutkiewicz J, Bradley M., Head J, Mittal K, Nam D, Basu N. Distribution of mercury in the chicken embryo and hatchling following methylmercury chloride egg injection. 33rd Annual Meeting, Society of Environmental Toxicology and Chemistry (SETAC), Boston, Massachusetts, United States, Nov 2011. [Poster]
Feng, K., Sun, H., Bradley, M., Dupler, E., Giannobile, W.V., Ma, P.X. 2010. Novel anti-bacterial nanofibrous PLLA scaffolds. Journal of Controlled Release 146, 363-369. LINK
Bradley, M., David, A., Heeren, T. Assessment of differences in microhabitat preferences between Drosera rotundifolia and Drosera intermedia in a northern Michigan bog. University of Michigan Biological Station Symposium, Aug 2010. [Platform]
Ma, P.X., Feng, K., and Bradley, M. Development and characterization of novel anti-bacterial PLLA nanofibrous scaffolds,Undergraduate Research Opportunities Program Symposium, Apr 2010. [Poster]
Ma, P.X., Feng, K., Bradley, M., and Dupler, E. Macroporous and nanofibrous polymer scaffolds and polymer/bone-like apatite composite scaffolds generated by sugar spheres. Undergraduate Research Opportunities Program Symposium, Apr 2009. [Poster]