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FOCAL AREA #4:
DRIED BLOOD SPOTS & EXPOSURE SCIENCE There is increasing interest in the use of dried blood spots as an exposure science tool particularly suited for studies on newborns, participants from low- and middle-income settings, and wildlife. We are focused on the development, validation, and application of new methods to measure essential and toxic elements in these samples. |
PROJECT AIMS
1) develop methods to quantify toxic and essential elements in dried blood spots;
2) apply dried blood spot methods in studies concerning newborn health, global health, and wildlife toxicology; and
3) engage with stakeholders concerning the adoption and institutionalization of these methods.
1) develop methods to quantify toxic and essential elements in dried blood spots;
2) apply dried blood spot methods in studies concerning newborn health, global health, and wildlife toxicology; and
3) engage with stakeholders concerning the adoption and institutionalization of these methods.
KEY PARTNERS
- Prof. Julius Fobil, University of Ghana Department of Biological, Environmental, and Occupational Health
- Prof. Rick Neitzel, University of Michigan School of Public Health
- Prof. Sung Kyun Park, University of Michigan School of Public Health
- Prof. Jill Baumgartner, McGill University
- Prof. Jonathan Chevrier, McGill University
- Dr. Bharat Chandramouli, AXYS Labs
- Arctic Shorebird Demographic Network (ASDN)
- Prof. Julius Fobil, University of Ghana Department of Biological, Environmental, and Occupational Health
- Prof. Rick Neitzel, University of Michigan School of Public Health
- Prof. Sung Kyun Park, University of Michigan School of Public Health
- Prof. Jill Baumgartner, McGill University
- Prof. Jonathan Chevrier, McGill University
- Dr. Bharat Chandramouli, AXYS Labs
- Arctic Shorebird Demographic Network (ASDN)
TOP FIVE KEY PUBLICATIONS / RESOURCES
1) Santa-Rios A, Barst BD, Basu N. 2020. Mercury Speciation in Whole Blood and Dried Blood Spots from Capillary and Venous Sources. Analytical Chemistry. 92(5): 3605-3612. doi: 10.1021/acs.analchem.9b04407
2) Rodríguez-Saldaña V, Fobil J, Basu N. 2020. Lead (Pb) exposure assessment in dried blood spots using Total Reflection X-Ray Fluorescence (TXRF). Environ Res. 2020 Nov 10:110444. doi: 10.1016/j.envres.2020.110444.
3) Pawly J, Neitzel R, Basu N. 2020. Analysis of copper, selenium, and zinc in newborn dried bloodspots using total reflection X-ray fluorescence (TXRF) spectroscopy. PeerJ Analytical Chemistry. 1:e1 https://doi.org/10.7717/peerj-achem.1
4) Basu N, Eng JWL, Perkins M, Santa-Rios A, Martincevic A, Carlson K, Neitzel R. 2017. Development and application of a novel method to characterize methylmercury exposure in newborns using dried blood spots. Environmental Research. 159: 276-282. LINK
5) Perkins M, Basu N. 2018. Dried blood spot for estimating mercury exposure in birds. Environmental Pollution. 236: 236-246.
1) Santa-Rios A, Barst BD, Basu N. 2020. Mercury Speciation in Whole Blood and Dried Blood Spots from Capillary and Venous Sources. Analytical Chemistry. 92(5): 3605-3612. doi: 10.1021/acs.analchem.9b04407
2) Rodríguez-Saldaña V, Fobil J, Basu N. 2020. Lead (Pb) exposure assessment in dried blood spots using Total Reflection X-Ray Fluorescence (TXRF). Environ Res. 2020 Nov 10:110444. doi: 10.1016/j.envres.2020.110444.
3) Pawly J, Neitzel R, Basu N. 2020. Analysis of copper, selenium, and zinc in newborn dried bloodspots using total reflection X-ray fluorescence (TXRF) spectroscopy. PeerJ Analytical Chemistry. 1:e1 https://doi.org/10.7717/peerj-achem.1
4) Basu N, Eng JWL, Perkins M, Santa-Rios A, Martincevic A, Carlson K, Neitzel R. 2017. Development and application of a novel method to characterize methylmercury exposure in newborns using dried blood spots. Environmental Research. 159: 276-282. LINK
5) Perkins M, Basu N. 2018. Dried blood spot for estimating mercury exposure in birds. Environmental Pollution. 236: 236-246.
KEY FUNDED PROJECTS
Funder: Gerber Foundation [2013-2015]
Title: Prenatal Exposure to Metals and Nutrients and Hearing
Neonatal blood spot samples to gauge in utero exposures to non-essential (lead, cadmium and mercury) and essential (calcium, iron, copper, zinc) elements in association with newborn hearing outcomes
Funder: U.S. NIH Fogarty International Center and Canada's IDRC [2015-2020]
Title: The West Africa-Michigan Collaborative Health Alliance for Reshaping Training, Education, and Research in Global Environmental and Occupational Health (WAM-CHARTER-GEOHealth)
Establish Ghana as a regional GEOHealth Hub of occupational and environmental health in West Africa.
Click here for NIH grant listing
Click here for our project website
Funder: Gerber Foundation [2013-2015]
Title: Prenatal Exposure to Metals and Nutrients and Hearing
Neonatal blood spot samples to gauge in utero exposures to non-essential (lead, cadmium and mercury) and essential (calcium, iron, copper, zinc) elements in association with newborn hearing outcomes
Funder: U.S. NIH Fogarty International Center and Canada's IDRC [2015-2020]
Title: The West Africa-Michigan Collaborative Health Alliance for Reshaping Training, Education, and Research in Global Environmental and Occupational Health (WAM-CHARTER-GEOHealth)
Establish Ghana as a regional GEOHealth Hub of occupational and environmental health in West Africa.
Click here for NIH grant listing
Click here for our project website